Article

Exploiting a metabolic vulnerability in brain tumour stem cells using a brain-penetrant drug with safe profile

2024-01-16

Abstract excerpt

Glioblastoma (GB) remains one of the most treatment refractory and fatal tumour in humans. GB contains a population of self-renewing stem cells, the brain tumour stem cells (BTSC) that are highly resistant to therapy and are at the origin of tumour relapse. Here, we report, for the first time, that mubritinib potently impairs stemness and growth of patient-derived BTSCs harboring different oncogenic mutations. Mec...

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Literature Corpus work: c8566804-be96-5dcb-b8a8-d7a467950053
DOI: 10.1101/2024.01.15.574967

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