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Article

Pyrvinium Targets CD133 in Human Glioblastoma Brain Tumor–Initiating Cells

7 Jul 2015

Abstract excerpt

PURPOSE: Clonal evolution of cancer may be regulated by determinants of stemness, specifically self-renewal, and current therapies have not considered how genetic perturbations or properties of stemness affect such functional processes. Glioblastoma-initiating cells (GICs), identified by expression of the cell surface marker CD133, are shown to be chemoradioresistant. In the current study, we sought to elucidate...

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PMID: 26152745
DOI: 10.1158/1078-0432.ccr-14-3147

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