Article
Case series of Li-Fraumeni syndrome: carcinogenic mechanisms in breast cancer with TP53 pathogenic variant carriers.
Breast cancer (Tokyo, Japan) - 1 Sept 2024
Hosonaga Mari, Habano Eri, Arakawa Hiromi, Kaneko Keika, Nakajima Takeshi, Hayashi Naomi, Fukada Ippei, Nakamura Akira, Haruyama Yurie, Maeda Tetsuyo, Inari Hitoshi, Kobayashi Takayuki, Nakashima Eri, Ueno Takayuki, Takano Toshimi, Takahashi Shunji, Ohno Shinji, Ueki Arisa
Abstract excerpt
BACKGROUND: Li-Fraumeni syndrome (LFS), a hereditary condition attributed to TP53 pathogenic variants,(PV), is associated with high risks for various malignant tumors, including breast cancer. Notably, individuals harboring TP53 PVs are more likely (67-83%) to develop HER2 + breast cancer than noncarriers (16-25%). In this retrospective study, we evaluated the associations between TP53 variants and breast cancer...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.