Article
Breast cancer phenotype in women with TP53 germline mutations: a Li-Fraumeni syndrome consortium effort.
Breast cancer research and treatment - 1 Jun 2012
Masciari Serena, Dillon Deborah A, Rath Michelle, Robson Mark, Weitzel Jeffrey N, Balmana Judith, Gruber Stephen B, Ford James M, Euhus David, Lebensohn Alexandra, Telli Melinda, Pochebit Stephen M, Lypas Georgios, Garber Judy E
Abstract excerpt
Breast cancer is the most common tumor in women with Li-Fraumeni Syndrome (LFS), an inherited cancer syndrome associated with germline mutations in the TP53 tumor suppressor gene. Their lifetime breast cancer risk is 49% by age 60. Breast cancers in TP53 mutation carriers recently have more often been reported to be hormone receptor and HER-2 positive by immunohistochemistry and FISH in small series. We seek to...
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