Article

<i>Bigh3</i> is essential for pulmonary fibrosis

2025-09-07

Abstract excerpt

Transforming growth factor beta (TGF- β) -induced g ene- h uman, clone 3 (BIGH3) has been implicated as a biomarker of lung fibrosis. However, it is unknown if BIGH3 plays a functional role in fibrosis pathogenesis. To address this question, we used in silico , in vitro and in vivo approaches. We found that BIGH3 / Bigh3 is upregulated in human lung fibrosis and mouse models of pulmonary fibrosis. We next...

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Literature Corpus work: c823e78d-7b74-53b9-8c28-6f59ea6d4a02
DOI: 10.1101/2025.09.02.673852

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