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Article

Hedgehog interacting protein-expressing lung fibroblasts suppress lymphocytic inflammation in mice.

JCI insight - 8 Sept 2021

Yun Jeong H, Lee ChangHee, Liu Tao, Liu Siqi, Kim Edy Y, Xu Shuang, Curtis Jeffrey L, Pinello Luca, Bowler Russell P, Silverman Edwin K, Hersh Craig P, Zhou Xiaobo

Abstract excerpt

Chronic obstructive pulmonary disease (COPD) is mainly caused by cigarette smoking and characterized by chronic inflammation in vulnerable individuals. However, it is unknown how genetic factors may shape chronic inflammation in COPD. To understand how hedgehog interacting protein, encoded by HHIP gene identified in the genome-wide association study in COPD, plays a role in inflammation, we utilized Hhip+/- mice...

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Topics

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Share to Cigarette Smoking
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Pulmonary Disease, Chronic Obstructive

Source

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Identifiers

PMID: 34375314
DOI: 10.1172/jci.insight.144575
PMCID: PMC8492352

Genes

HHIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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