Article

Phosphodiesterase function and activity in isolated cardiomyocytes from rat, guinea pig and human heart

2009-01-01

Abstract excerpt

Phosphodiesterases (PDEs) play a key role in the control of cardiac contraction. PDE inhibitors are associated with cardiotoxicity, and increased knowledge of cardiomyocyte PDEs is required for improved pharmaceutical development. PDE activity and function were compared in animal and human cardiomyocytes in order to determine a suitable model for the human response, and to generate new insights into the role of ca...

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Identifiers and source

Literature Corpus work: 80f20262-b6ed-5fbb-8ebb-16f8fc741498
DOI: 10.25560/4414

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