Uncoordinated centrosome cycle underlies the instability of non-diploid somatic cells in mammals

Abstract excerpt

In animals, somatic cells are usually diploid and are unstable when haploid for unknown reasons. In this study, by comparing isogenic human cell lines with different ploidies, we found frequent centrosome loss specifically in the haploid state, which profoundly contributed to haploid instability through subsequent mitotic defects. We also found that the efficiency of centriole licensing and duplication changes...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Microtubule and mitosis dynamics
• Share to Pluripotent Stem Cells Research
• Share to Reproductive Biology and Fertility