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Article

A novel knockout mouse for the small EDRK-rich factor 2 (Serf2) showing developmental and other deficits.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Apr 2021

Cleverley Karen, Lee Weaverly Colleen, Mumford Paige, Collins Toby, Rickman Matthew, Cunningham Thomas J, Cleak James, Mianne Joffrey, Szoke-Kovacs Zsombor, Stewart Michelle, Teboul Lydia, Maduro Cheryl, Wells Sara, Wiseman Frances K, Fisher Elizabeth M C

Abstract excerpt

The small EDRK-rich factor 2 (SERF2) is a highly conserved protein that modifies amyloid fibre assembly in vitro and promotes protein misfolding. However, the role of SERF2 in regulating age-related proteotoxicity remains largely unexplored due to a lack of in vivo models. Here, we report the generation of Serf2 knockout mice using an ES cell targeting approach, with Serf2 knockout alleles being bred onto...

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Identifiers

PMID: 33713180
DOI: 10.1007/s00335-021-09864-6
PMCID: PMC8012326

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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