Article

FORGE: A tool to discover cell specific enrichments of GWAS associated SNPs in regulatory regions

2015-01-22

Abstract excerpt

Genome Wide Association Studies (GWAS) provide an unbiased discovery mechanism for numerous human diseases. However, a frustration in the analysis of GWAS is that the majority of variants discovered do not directly alter protein-coding genes. We have developed a simple analysis approach that detects the tissue-specific regulatory component of a set of GWAS SNPs by identifying enrichment of overlap with DNase I hot...

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Literature Corpus work: c7a1dde0-ca39-57f5-98b4-a18165132166
DOI: 10.12688/f1000research.6032.1

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