Article

FORGE: A tool to discover cell specific enrichments of GWAS associated SNPs in regulatory regions

2014-12-20

Abstract excerpt

Genome wide association studies provide an unbiased discovery mechanism for numerous human diseases. However, a frustration in the analysis of GWAS is that the majority of variants discovered do not directly alter protein-coding genes. We have developed a simple analysis approach that detects the tissue-specific regulatory component of a set of GWAS SNPs by identifying enrichment of overlap with DNase I hotspots f...

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Literature Corpus work: 3fcc67ca-11ce-505b-92a3-01fd0edda7de
DOI: 10.1101/013045

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