Article

GARFIELD - GWAS Analysis of Regulatory or Functional Information Enrichment with LD correction

2016-11-07

Abstract excerpt

Loci discovered by genome-wide association studies (GWAS) predominantly map outside protein-coding genes. The interpretation of functional consequences of non-coding variants can be greatly enhanced by catalogs of regulatory genomic regions in cell lines and primary tissues. However, robust and readily applicable methods are still lacking to systematically evaluate the contribution of these regions to genetic vari...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: addf1179-506f-59ad-ab93-bdf4865f614c
DOI: 10.1101/085738

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

GARFIELD - GWAS Analysis of Regulatory or Functional Information Enrichment with LD correctionDOI 10.1101/085738Read

GREGOR: evaluating global enrichment of trait-associated variants in epigenomic features using a systematic, data-driven approach.Semantic proximity Read

The Post-GWAS Era: From Association to Function.Semantic proximity Read

Functional enrichments of disease variants across thousands of independent loci in eight diseasesSemantic proximity Read

Leveraging polygenic functional enrichment to improve GWAS powerSemantic proximity Read

Systematic differences in discovery of genetic effects on gene expression and complex traits.Semantic proximity Read

Regulatory landscape enrichment analysis (RLEA): a computational toolkit for non-coding variant enrichment and cell type prioritization.Semantic proximity Read

Predicting trait regulators by identifying co-localization of DNA binding and GWAS variants in regulatory regionsSemantic proximity Read

A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids.Semantic proximity Read

Modeling Regulatory Network Topology Improves Genome-Wide Analyses of Complex Human TraitsSemantic proximity Read

Modeling regulatory network topology improves genome-wide analyses of complex human traits.Semantic proximity Read

The landscape of GWAS validation; systematic review identifying 309 validated non-coding variants across 130 human diseases.Semantic proximity Read

Probabilistic inference of the genetic architecture underlying functional enrichment of complex traits.Semantic proximity Read