Article

Unusual mode of dimerization of retinitis pigmentosa-associated F220C rhodopsin

2020-12-29

Abstract excerpt

Mutations in the G protein-coupled receptor (GPCR) rhodopsin are a common cause of autosomal dominant retinitis pigmentosa, a blinding disease. Rhodopsin self-associates in the membrane, and the purified monomeric apo-protein opsin dimerizes in vitro as it transitions from detergent micelles to reconstitute into a lipid bilayer. We previously reported that the retinitis pigmentosa-linked F220C opsin mutant fails...

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Literature Corpus work: c79bc21b-ee72-5ad5-ae78-0174fb8ec21d
DOI: 10.1101/2020.12.28.424580

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