Article
A G Protein-Coupled Receptor Dimerization Interface in Human Cone Opsins.
Biochemistry - 10 Jan 2017
Jastrzebska Beata, Comar William D, Kaliszewski Megan J, Skinner Kevin C, Torcasio Morgan H, Esway Anthony S, Jin Hui, Palczewski Krzysztof, Smith Adam W
Abstract excerpt
G protein-coupled receptors (GPCRs) detect a wide variety of physical and chemical signals and transmit that information across the cellular plasma membrane. Dimerization is a proposed modulator of GPCR signaling, but the structure and stability of class A GPCR dimerization have been difficult to establish. Here we investigated the dimerization affinity and binding interface of human cone opsins, which initiate...
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