Article
The microenvironments of multistage carcinogenesis.
Seminars in cancer biology - 1 Oct 2008
Laconi Ezio, Doratiotto Silvia, Vineis Paolo
Abstract excerpt
Overt neoplasia is often the result of a chronic disease process encompassing an extended segment of the lifespan of any species. A common pathway in the natural history of the disease is the appearance of focal proliferative lesions that are known to act as precursors for cancer development. It is becoming increasingly apparent that the emergence of such lesions is not a cell-autonomous phenomenon, but is...
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