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Article

Heme oxygenase promotes B-Raf-dependent melanosphere formation.

Pigment cell & melanoma research - 1 Nov 2020

Jasmer Kimberly J, Hou Jie, Mannino Philip, Cheng Jianlin, Hannink Mark

Abstract excerpt

Biosynthesis and degradation of heme, an iron-bound protoporphyrin molecule utilized by a wide variety of metabolic processes, are tightly regulated. Two closely related enzymes, heme oxygenase 1 (HMOX1) and heme oxygenase 2 (HMOX2), degrade free heme to produce carbon monoxide, Fe2+ , and biliverdin. HMOX1 expression is controlled via the transcriptional activator, NFE2L2, and the transcriptional repressor,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32558263
DOI: 10.1111/pcmr.12905
PMCID: PMC7572722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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