Article

Cardiomyocyte-specific plakophilin-2 loss is sufficient to induce aging and senescence of nonmyocytes. Relevance to arrhythmogenic cardiomyopathy

2025-10-23

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Introduction</h4> Pathogenic variants in PKP2 are the most common cause of familial arrhythmogenic right ventricular cardiomyopathy (ARVC). <h4>Objective</h4> To test whether PKP2 deficiency only in cardiomyocytes is sufficient to provoke premature aging and pro-inflammatory senescence in non-myocytes, cardiac resident cells. <h4>Methods</h4> We studied mice with cardiomyocyte-specific,...

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Literature Corpus work: 90e36044-610d-57bc-8fdc-3d29a1c0e49c
DOI: 10.1101/2025.10.22.682160

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Cardiomyocyte-specific plakophilin-2 loss is sufficient to induce aging and senescence of nonmyocytes. Relevance to arrhythmogenic cardiomyopathyDOI 10.1101/2025.10.22.682160Read

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