Article

Molecular characterization of Rft1, an ER membrane protein associated with congenital disorder of glycosylation RFT1-CDG

2024-04-03

Abstract excerpt

<h4>ABSTRACT</h4> The oligosaccharide needed for protein N -glycosylation is assembled on a lipid carrier via a multi-step pathway. Synthesis is initiated on the cytoplasmic face of the endoplasmic reticulum (ER) and completed on the luminal side after transbilayer translocation of a heptasaccharide lipid intermediate. More than 30 Congenital Disorders of Glycosylation (CDGs) are associated with this pathway, in...

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Literature Corpus work: 9ac2aa3e-e932-5de0-a932-1d7b16b165e0
DOI: 10.1101/2024.04.03.587922

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