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Article

Similarity of molecular phenotype between known epilepsy gene LGI1 and disease candidate gene LGI2.

BMC biochemistry - 24 Sept 2010

Limviphuvadh Vachiranee, Chua Ling Ling, Rahim Rabi Atul Adawiyah Bte, Eisenhaber Frank, Maurer-Stroh Sebastian, Adhikari Sharmila

Abstract excerpt

BACKGROUND: The LGI2 (leucine-rich, glioma inactivated 2) gene, a prime candidate for partial epilepsy with pericentral spikes, belongs to a family encoding secreted, beta-propeller domain proteins with EPTP/EAR epilepsy-associated repeats. In another family member, LGI1 (leucine-rich, glioma inactivated 1) mutations are responsible for autosomal dominant lateral temporal epilepsy (ADLTE). Because a few LGI1...

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Share to Epilepsies, Partial
Share to Epilepsy, Temporal Lobe

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Signaling Peptides and Proteins

Share to Mutation, Missense

Share to Phylogeny

Share to Polymorphism, Single Nucleotide

Share to Protein Structure, Tertiary

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Source

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Identifiers

PMID: 20863412
DOI: 10.1186/1471-2091-11-39
PMCID: PMC2949613

Genes

LGI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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