Article

Regulation of the transcriptome, miRNAs, and alternative splicing in a FSGS zebrafish injury model

2025-07-11

Abstract excerpt

<h4>Background</h4> Focal Segmental Glomerulosclerosis (FSGS) is a severe kidney disorder with complex and not yet fully understood pathogenesis. Alternative splicing (AS) – the generation of distinct protein isoforms from the same gene – might play a critical role by the regulation of gene functions and disease development. <h4>Methods</h4> To investigate the role of AS in FSGS, we used a zebrafish model, which...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c748b4e3-237a-515b-ad52-f9bcafe31383
DOI: 10.1101/2025.07.09.663814

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Regulation of the transcriptome, miRNAs, and alternative splicing in a FSGS zebrafish injury modelDOI 10.1101/2025.07.09.663814Read

A Bigenic mouse model of FSGS reveals perturbed pathways in podocytes, mesangial cells and endothelial cellsSemantic proximity Read

RNA Alternative Splicing and Polyadenylation and Regulation of the Glomerular Filtration BarrierSemantic proximity Read

Transcriptional profiling of the zebrafish proximal tubuleSemantic proximity Read

A Novel Missense Mutation of Wilms’ Tumor 1 Causes Autosomal Dominant FSGSSemantic proximity Read

Integration of Cistromic and Transcriptomic Analyses Identifies Nphs2, Mafb, and Magi2 as Wilms’ Tumor 1 Target Genes in Podocyte Differentiation and MaintenanceSemantic proximity Read

Identification of ARMH4 and WIPF3 as human podocyte proteins with potential roles in immunomodulation and cytoskeletal dynamicsSemantic proximity Read

Fibronectin and Hand2 influence tubulogenesis during pronephros development and mesonephros regeneration in zebrafish (Danio rerio).Semantic proximity Read

Alternative splicing in mechanically stretched podocytes as a model of glomerular hypertensionSemantic proximity Read

Laser Capture Microdissection-Microarray Analysis of Focal Segmental Glomerulosclerosis GlomeruliSemantic proximity Read

A Comprehensive Map of mRNAs and Their Isoforms across All 14 Renal Tubule Segments of MouseSemantic proximity Read

Human pluripotent stem cell-derived kidney organoids reveal tubular epithelial pathobiology of heterozygous <i>HNF1B</i> -associated dysplastic kidney malformationsSemantic proximity Read

The genetic basis of FSGS and steroid-resistant nephrosis.Semantic proximity Read