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Article

Transcriptional profiling of the zebrafish proximal tubule

12 Jun 2019

Abstract excerpt

The hepatocyte nuclear factor-1β (Hnf1b) transcription factor is a key regulator of kidney tubule formation and is associated with a syndrome of renal cysts and early onset diabetes. To further our understanding of Hnf1b in the developing zebrafish kidney, we performed RNA sequencing analysis of proximal tubules from hnf1b-deficient larvae. This analysis revealed an enrichment of gene transcripts encoding...

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PMID: 31188030
DOI: 10.1152/ajprenal.00174.2019

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