Article
New perspectives in the treatment of adult medulloblastoma in the era of molecular oncology.
Critical reviews in oncology/hematology - 1 Jun 2015
Brandes Alba A, Bartolotti Marco, Marucci Gianluca, Ghimenton Claudio, Agati Raffaele, Fioravanti Antonio, Mascarin Maurizio, Volpin Lorenzo, Ammannati Franco, Masotto Barbara, Gardiman Marina Paola, De Biase Dario, Tallini Giovanni, Crisi Girolamo, Bartolini Stefania, Franceschi Enrico
Abstract excerpt
Medulloblastoma is the most common central nervous system tumor in children, while it is extremely rare in adults. Multimodal treatment involving surgery, radiotherapy and chemotherapy can improve the prognosis of this disease, and recent advances in molecular biology have allowed the identification of molecular subgroups (WNT, SHH, Groups 3 and 4), each of which have different cytogenetic, mutational and gene...
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