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Article

Activation of hypoxia-inducible factor-2 in adipocytes results in pathological cardiac hypertrophy.

Journal of the American Heart Association - 10 Dec 2013

Lin Qun, Huang Yan, Booth Carmen J, Haase Volker H, Johnson Randall S, Celeste Simon M, Giordano Frank J, Yun Zhong

Abstract excerpt

BACKGROUND: Obesity can cause structural and functional abnormalities of the heart via complex but largely undefined mechanisms. Emerging evidence has shown that obesity results in reduced oxygen concentrations, or hypoxia, in adipose tissue. We hypothesized that the adipocyte hypoxia-signaling pathway plays an essential role in the development of obesity-associated cardiomyopathy. METHODS AND RESULTS: Using a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24326162
DOI: 10.1161/JAHA.113.000548
PMCID: PMC3886757

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