Article

SEMA4C is a novel target to limit osteosarcoma growth, progression, and metastasis

2019-01-14

Abstract excerpt

Semaphorins, specifically type IV, are important regulators of axonal guidance and have been increasingly implicated in poor prognoses in a number of different solid cancers. In conjunction with their cognate PLXNB family receptors, type IV members have been increasingly shown to mediate oncogenic functions necessary for tumor development and malignant spread. In this study, we investigated the role of semaphorin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c703b490-e83b-5d9f-bf59-d29bc4576912
DOI: 10.1101/520452

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SEMA4C is a novel target to limit osteosarcoma growth, progression, and metastasisDOI 10.1101/520452Read

SEMA3F prevents metastasis of colorectal cancer by PI3K–AKT‐dependent down‐regulation of the ASCL2–CXCR4 axisSemantic proximity Read

The HIF-1α/Sema4D axis promotes hypoxia-induced metastasis of human osteosarcoma via PI3K/Akt/mTOR signaling pathwaySemantic proximity Read

The emerging role of class-3 semaphorins and their neuropilin receptors in oncologySemantic proximity Read

CNTNAP4 signaling regulates osteosarcoma disease progressionSemantic proximity Read

Dual Role of SnoN in Mammalian TumorigenesisSemantic proximity Read

Semaphorin 3F inhibits breast cancer metastasis by regulating the Akt-mTOR and TGFβ signaling pathways via neuropilin-2Semantic proximity Read

RanBP9/TSSC3 complex cooperates to suppress anoikis resistance and metastasis via inhibiting Src-mediated Akt signaling in osteosarcoma.Semantic proximity Read

SEMA4D Knockdown Attenuates β‐Catenin‐Dependent Tumor Progression in Colorectal CancerSemantic proximity Read

ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expressionSemantic proximity Read

LIM-Only Protein 4 (LMO4) and LIM Domain Binding Protein 1 (LDB1) Promote Growth and Metastasis of Human Head and Neck Cancer (LMO4 and LDB1 in Head and Neck Cancer)Semantic proximity Read

Clinically-observed FOXA1 mutations upregulate SEMA3C through transcriptional derepression in prostate cancer.Semantic proximity Read

Tumour growth inhibition and anti-metastatic activity of a mutated furin-resistant Semaphorin 3E isoform.Semantic proximity Read