Article

The HIF-1α/Sema4D axis promotes hypoxia-induced metastasis of human osteosarcoma via PI3K/Akt/mTOR signaling pathway

2022-05-05

Abstract excerpt

<h4>Purpose: </h4> Semaphorin 4D (Sema4D) plays a vital role in varied tumor biological processes. Hypoxia inducible factor-1α (HIF-1α), an essential regulatory factor in tumor microenvironment, mediates hypoxia-induced-oncogenes overexpression during cancer occurrence and development. However, the function of Sema4D and its connection with HIF-1α are not entirely validated in osteosarcoma. <h4>Methods: </h4> RT-q...

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Literature Corpus work: 7045a363-fa46-5586-8047-16e0eeacc0c3
DOI: 10.21203/rs.3.rs-1617973/v1

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