Article
Clinical outcomes associated with NPM1 mutations in newly diagnosed acute myeloid leukemia.
Cancer - 15 Aug 2026
Farhat Aziz, El Hajjar Georgina, Kantarjian Hagop, Sasaki Koji, Short Nicholas J, Cuglievan Branko, Loghavi Sanam, Patel Keyur, Bataller Alex, Jen Wei Ying, Yilmaz Musa, Montalban-Bravo Guillermo, Hammond Danielle, Pemmaraju Naveen, Daver Naval, Ravandi Farhad, Jabbour Elias, Kadia Tapan, Borthakur Gautam, Garcia-Manero Guillermo, DiNardo Courtney D, Issa Ghayas C
Abstract excerpt
BACKGROUND: Nucleophosmin 1-mutated (NPM1mt) acute myeloid leukemia (AML) is associated with a relatively favorable prognosis though long-term outcomes remain suboptimal without clear predictors identified by therapy. METHODS: In a retrospective analysis, the authors identified 396 patients (18%) with newly diagnosed (ND) NPM1mt AML treated at The University of Texas MD Anderson Cancer Center and analyzed their...
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