Prognostic significance of NPM1 mutations in the absence of FLT3-internal tandem duplication in older patients with acute myeloid leukemia: a SWOG and UK National Cancer Research Institute/Medical Research Council report.

doi:10.1200/JCO.2014.58.0571

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Article

Prognostic significance of NPM1 mutations in the absence of FLT3-internal tandem duplication in older patients with acute myeloid leukemia: a SWOG and UK National Cancer Research Institute/Medical Research Council report.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Apr 2015

Ostronoff Fabiana, Othus Megan, Lazenby Michelle, Estey Elihu, Appelbaum Frederick R, Evans Anna, Godwin John, Gilkes Amanda, Kopecky Kenneth J, Burnett Alan, List Alan F, Fang Min, Oehler Vivian G, Petersdorf Stephen H, Pogosova-Agadjanyan Era L, Radich Jerald P, Willman Cheryl L, Meshinchi Soheil, Stirewalt Derek L

Abstract excerpt

PURPOSE: Younger patients with acute myeloid leukemia (AML) harboring NPM1 mutations without FLT3-internal tandem duplications (ITDs; NPM1-positive/FLT3-ITD-negative genotype) are classified as better risk; however, it remains uncertain whether this favorable classification can be applied to older patients with AML with this genotype. Therefore, we examined the impact of age on the prognostic significance of...

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Identifiers

PMID: 25713434
DOI: 10.1200/JCO.2014.58.0571
PMCID: PMC4372852

Genes

FLT3
NPM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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