Article

Assessing molecular gene by treatment interactions using a population of neural progenitors exposed to valproic acid and lithium

2025-09-14

Abstract excerpt

Gene by treatment (GxT) interactions likely contribute to variability in clinical response, but are difficult to identify in population studies. Here, we applied psychiatric and neurological disorder treatments to a genotyped population of human neural progenitors (n=83 donors) and measured molecular responses on chromatin accessibility and gene expression. Gene regulatory responses to valproic acid (VPA), which i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c6d81a09-5699-5f1c-8ca6-313694cc304a
DOI: 10.1101/2025.09.12.25335653

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Assessing molecular gene by treatment interactions using a population of neural progenitors exposed to valproic acid and lithiumDOI 10.1101/2025.09.12.25335653Read

Assessing molecular gene by treatment interactions using a population of neural progenitors exposed to valproic acid and lithium.Semantic proximity Read

Systematic analysis of genetic and phenotypic characteristics reveals antisense oligonucleotide therapy potential for one-third of neurodevelopmental disordersSemantic proximity Read

Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomicsSemantic proximity Read

Transcription factor binding and individual genetic risk for valproate teratogenicitySemantic proximity Read

Transcription Factor Binding and Individual Genetic Risk of Valproate Teratogenicity.Semantic proximity Read

Linking GWAS to pharmacological treatments for psychiatric disordersSemantic proximity Read

Oxygen-induced stress reveals context-specific gene regulatory effects in human brain organoidsSemantic proximity Read

Cell villages and Dirichlet modeling map human cell fitness geneticsSemantic proximity Read

Epigenomic mapping and effect sizes of noncoding variants associated with psychotropic drug response.Semantic proximity Read

Molecular Profiling of Genes Associated With Methylphenidate Pathway Therapy and Discovery of New Variants in Amazonian Amerindian Populations.Semantic proximity Read

Systematic analysis of genetic and phenotypic characteristics reveals antisense oligonucleotide therapy potential for one-third of neurodevelopmental disorders.Semantic proximity Read

DetectGxT: detecting gene-by-treatment interactions on molecular count phenotypes accounting for allelic additivitySemantic proximity Read