Article

Linking GWAS to pharmacological treatments for psychiatric disorders

2022-05-16

Abstract excerpt

<h4>Importance</h4> Large-scale genome-wide association studies (GWASs) are expected to inform the development of pharmacological treatments, however the mechanisms of correspondence between the genetic liability identified through GWASs and disease pathophysiology are not well understood. <h4>Objective</h4> To investigate whether functional information from a range of open bioinformatics datasets can elucidate th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 95322161-47be-5b7e-8dfe-3f28dced1426
DOI: 10.1101/2022.05.11.22274981

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Linking GWAS to pharmacological treatments for psychiatric disordersDOI 10.1101/2022.05.11.22274981Read

Psychiatric genome-wide association study enrichment shows promise for future psychopharmaceutical discoveriesSemantic proximity Read

Mendelian Randomization Using the Druggable Genome Reveals Genetically Supported Drug Targets for Psychiatric Disorders.Semantic proximity Read

Translating genome-wide association findings into new therapeutics for psychiatry.Semantic proximity Read

Psychiatric Genome-wide Association Study Enrichment Shows Promise for Future Psychopharmaceutical DiscoveriesSemantic proximity Read

Leveraging the Genetics of Psychiatric Disorders to Prioritize Potential Drug Targets and CompoundsSemantic proximity Read

Leveraging the genetics of psychiatric disorders to prioritize potential drug targets and compounds.Semantic proximity Read

The Psychiatric Genomics Consortium: Discoveries and DirectionsSemantic proximity Read

Analysis of genetic differences between psychiatric disorders: exploring pathways and cell types/tissues involved and ability to differentiate the disorders by polygenic scores.Semantic proximity Read

When GWAS meets the Connectivity Map: drug repositioning for seven psychiatric disordersSemantic proximity Read