Assessing molecular gene by treatment interactions using a population of neural progenitors exposed to valproic acid and lithium.

Abstract excerpt

Gene by treatment (GxT) interactions likely contribute to variability in clinical response, but are difficult to identify in population studies. Here, we applied psychiatric and neurological disorder treatments to a genotyped population of human neural progenitors (n = 83 donors) and measured molecular responses on chromatin accessibility and gene expression. Gene regulatory responses to valproic acid (VPA),...

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• Folic Acid
• Gene-Environment Interaction
• Genome-Wide Association Study
• Lithium
• Mental Disorders