Molecular Profiling of Genes Associated With Methylphenidate Pathway Therapy and Discovery of New Variants in Amazonian Amerindian Populations.

doi:10.1002/ajmg.b.33064

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Article

Molecular Profiling of Genes Associated With Methylphenidate Pathway Therapy and Discovery of New Variants in Amazonian Amerindian Populations.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jun 2026

Santos Aline Pasquini, de Souza Tatiane Carinta, Aguiar Kaio Evandro Cardoso, da Costa Ana Caroline Alves, Monte Natasha, Rodrigues Juliana Carla Gomes, Nunes Giovanna Gilioli da Costa, Coelho Rita de Cássia Calderaro, Ribeiro-Dos-Santos Ândrea, Dos Santos André Maurício Ribeiro, de Souza Sandro José, Dos Santos Sidney Emanuel Batista, Burbano Rommel Mario Rodriguez, Fernandes Marianne Rodrigues, Dos Santos Ney Pereira Carneiro

Abstract excerpt

In Attention Deficit Hyperactivity Disorder (ADHD), methylphenidate is one of the most widely used drugs, in which patient response significantly impacts prognosis. This study aimed to characterize the molecular profile of 10 genes associated with methylphenidate therapy. Whole-exome sequencing of 64 indigenous individuals from 12 different indigenous populations in the Amazon was used. A total of 143 genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Catechol O-Methyltransferase

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Identifiers

PMID: 41058112
DOI: 10.1002/ajmg.b.33064

Genes

ADGRL3
ADRA2A
COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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