Article

MORPHIS (MORPHological Interpretable Signature) captures heterogeneous treatment- and aging-related responses of single cells

2026-03-25

Abstract excerpt

Cell morphology encodes changes in cytoskeletal and organelle organization during disease, treatment, and aging, yet is often assessed qualitatively or through poorly interpretable feature sets extracted from microscopy images. Here we introduce MORPHIS (MORPHological Interpretable Signature), a machine learning framework on explainable, analytically rich features paired with statistical methodologies for robust a...

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Literature Corpus work: c6d76c8c-aaff-5d67-854f-e267d4642275
DOI: 10.64898/2026.03.24.713910

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