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Novel lactylation-related signature to predict prognosis for pancreatic adenocarcinoma

17 May 2024

Abstract excerpt

BACKGROUND Lactate, previously considered a metabolic byproduct, is pivotal in cancer progression and maintaining the immunosuppressive tumor microenvironment. Further investigations confirmed that lactate is a primary regulator, introducing recently described post-translational modifications of histone and non-histone proteins, termed lysine lactylation. Pancreatic adenocarcinomas are characterized by increased...

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PMID: 38817665
DOI: 10.3748/wjg.v30.i19.2575

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