Article

Extracellular vesicles facilitate the horizontal transfer of drug resistance and stem-like properties between ovarian tumor cells

2026-01-23

Abstract excerpt

Ovarian cancer stem cells (CSCs) can seed recurrent drug-resistant disease. Likewise, non-CSCs can acquire CSC phenotypic properties. How this process is orchestrated is of interest to inform how it might be prevented. We tested the hypothesis that ovarian CSC and/or drug-resistant tumor cells confer stem-like properties via extracellular vesicles (EVs). We focused our investigation on how EVs might mediate EZH2 s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c699ab52-4385-5869-aff5-c9b8a7677cfc
DOI: 10.64898/2026.01.20.699925

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Extracellular vesicles facilitate the horizontal transfer of drug resistance and stem-like properties between ovarian tumor cellsDOI 10.64898/2026.01.20.699925Read

Ovarian cancer stem cell-specific gene expression profiling and targeted drug prescreeningSemantic proximity Read

Characterization of stem cell and cancer stem cell populations in ovary and ovarian tumorsSemantic proximity Read

Ovarian Cancer Stem Cell–Like Side Populations Are Enriched Following Chemotherapy and Overexpress <i>EZH2</i>Semantic proximity Read

Modeling platinum resistance in a stem-like patient-derived ovarian cancer sampleSemantic proximity Read

Tumor microenvironment-induced FOXM1 regulates ovarian cancer stemnessSemantic proximity Read

Cancer Stem Cells in Ovarian Cancer—A Source of Tumor Success and a Challenging Target for Novel TherapiesSemantic proximity Read

Hypoxia-induced exosomes contribute to a more aggressive and chemoresistant ovarian cancer phenotype: a novel mechanism linking STAT3/Rab proteins.Semantic proximity Read

Ovarian carcinoma tumor-initiating cells have a mesenchymal phenotypeSemantic proximity Read

The role of cancer stem cells and the side population in epithelial ovarian cancer.Semantic proximity Read

Platinum-Induced Mitochondrial OXPHOS Contributes to Cancer Stem Cell Enrichment in Ovarian CancerSemantic proximity Read

Extracellular vesicles in anti-tumor drug resistance: Mechanisms and therapeutic prospectsSemantic proximity Read

A novel ALDH1A1 inhibitor blocks platinum-induced senescence and stemness in ovarian cancerSemantic proximity Read