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Article

Hypoxia-induced exosomes contribute to a more aggressive and chemoresistant ovarian cancer phenotype: a novel mechanism linking STAT3/Rab proteins.

Oncogene - 1 Jul 2018

Dorayappan Kalpana Deepa Priya, Wanner Ross, Wallbillich John J, Saini Uksha, Zingarelli Roman, Suarez Adrian A, Cohn David E, Selvendiran Karuppaiyah

Abstract excerpt

Hypoxia-mediated tumor progression, metastasis, and drug resistance are major clinical challenges in ovarian cancer. Exosomes released in the hypoxic tumor microenvironment may contribute to these challenges by transferring signaling proteins between cancer cells and normal cells. We observed that ovarian cancer cells exposed to hypoxia significantly increased their exosome release by upregulating Rab27a,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29636548
DOI: 10.1038/s41388-018-0189-0
PMCID: PMC6043362

Genes

STAT3
FAS
LAMP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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