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Article

Ovarian Cancer Stem Cell–Like Side Populations Are Enriched Following Chemotherapy and Overexpress <i>EZH2</i>

7 Jan 2011

Abstract excerpt

Platinum-based chemotherapy, with cytoreductive surgery, is the cornerstone of treatment of advanced ovarian cancer; however, acquired drug resistance is a major clinical obstacle. It has been proposed that subpopulations of tumor cells with stem cell-like properties, such as so-called side populations (SP) that overexpress ABC drug transporters, can sustain the growth of drug-resistant tumor cells, leading to...

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PMID: 21216927
DOI: 10.1158/1535-7163.mct-10-0788

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