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Article

Three functionally distinct classes of cGAS proteins in nature revealed by self-DNA-induced interferon responses

2022-03-09

Abstract excerpt

Innate immune pattern recognition receptors (PRRs) emerged early in evolution. It is generally assumed that structurally homologous proteins in distinct species will operate via similar mechanisms. We tested this prediction through the study of interferon responses to self-DNA by the enzymatic PRR cyclic GMP-AMP synthase (cGAS). Contrary to expectations, we identified three functional classes of this PRR in mammal...

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Identifiers and source

Literature Corpus work
c68a67e4-657f-578e-9a9f-7409419acfe7
DOI
10.1101/2022.03.09.483681
Open publication

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Three functionally distinct classes of cGAS proteins in nature revealed by self-DNA-induced interferon responsesDOI 10.1101/2022.03.09.483681
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