Self-Awareness: Nucleic Acid–Driven Inflammation and the Type I Interferonopathies

Abstract excerpt

Recognition of foreign nucleic acids is the primary mechanism by which a type I interferon-mediated antiviral response is triggered. Given that human cells are replete with DNA and RNA, this evolutionary strategy poses an inherent biological challenge, i.e., the fundamental requirement to reliably differentiate self-nucleic acids from nonself nucleic acids. We suggest that the group of Mendelian inborn errors of...

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• interferon and immune responses
• RNA regulation and disease
• Viral Infections and Immunology Research