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Leveraging a synthetic biology approach to enhance BCG-mediated expansion of Vγ9Vδ2 T cells

2025-05-09

Abstract excerpt

There is an urgent need to develop a more efficacious anti-tuberculosis vaccine as the current live-attenuated vaccine strain BCG fails to prevent pulmonary infection in adults. Our long-term goal is to test whether increasing the immunogenicity of BCG will improve vaccine effectiveness while maintaining its proven safety profile. In this study, we leverage a synthetic biology approach to engineer BCG to produce m...

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Literature Corpus work
c67bc0ad-7943-5d63-881a-fffed5ae3ad3
DOI
10.1101/2025.05.05.651767
Open publication

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Leveraging a synthetic biology approach to enhance BCG-mediated expansion of Vγ9Vδ2 T cellsDOI 10.1101/2025.05.05.651767
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