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Genetic Modification of the BCG Vaccine to Overcome Its Limited Efficacy in Adults: A Specialized Review

2026-01-29

Abstract excerpt

<title>Abstract</title> <p>While the Bacillus Calmette-Guérin (BCG) vaccine protects against severe childhood tuberculosis, it does not consistently protect against adult pulmonary tuberculosis, the main driver of global transmission and mortality. This review summarizes the scientific rationale and evolution of genetic engineering approaches to address BCG's immunological limitations, from initial strategies suc...

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Literature Corpus work
0c130b85-da62-5e77-9d0a-ced10879a13c
DOI
10.21203/rs.3.rs-8714621/v1
Open publication

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Genetic Modification of the BCG Vaccine to Overcome Its Limited Efficacy in Adults: A Specialized ReviewDOI 10.21203/rs.3.rs-8714621/v1
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