Article

Electrostatics Govern Protein Orientation on Citrate-Capped Gold Nanoparticles

2025-11-10

Abstract excerpt

Conjugation of proteins with gold nanoparticles (GNPs) is crucial in developing nanoparticle-based drugs, which are used in making targeted delivery systems for therapeutic and diagnostic use. This conjugation is often mediated by covalent gold–thiol (Au-S) bonds involving cysteine residues. However, the influence of other interactions, like electrostatics, on protein-GNP interactions remains poorly understood. Wh...

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Literature Corpus work: c668a606-2faa-5b08-9c79-642129ef8de3
DOI: 10.1101/2025.11.07.687172

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