Article
Secreted biomolecules alter the biological identity and cellular interactions of nanoparticles.
ACS nano - 24 Jun 2014
Albanese Alexandre, Walkey Carl D, Olsen Jonathan B, Guo Hongbo, Emili Andrew, Chan Warren C W
Abstract excerpt
A nanoparticle's physical and chemical properties at the time of cell contact will determine the ensuing cellular response. Aggregation and the formation of a protein corona in the extracellular environment will alter nanoparticle size, shape, and surface properties, giving it a "biological identity" that is distinct from its initial "synthetic identity". The biological identity of a nanoparticle depends on the...
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