Article
Amelioration of oxidative stress-induced phenotype loss of parvalbumin interneurons might contribute to the beneficial effects of environmental enrichment in a rat model of post-traumatic stress disorder.
Behavioural brain research - 1 Oct 2016
Sun Xiao R, Zhang Hui, Zhao Hong T, Ji Mu H, Li Hui H, Wu Jing, Li Kuan Y, Yang Jian J
Abstract excerpt
Post-traumatic stress disorder (PTSD) is a common psychiatric disease following exposure to a severe traumatic event or physiological stress, which is characterized by anxiety- and depression-like behaviors and cognitive impairment. However, the underlying mechanisms remain elusive. Parvalbumin (PV) interneurons that are susceptible to oxidative stress are a subset of inhibitory GABAergic neurons regulating the...
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