Article

Dualsteric and dual-acting modulation of muscarinic receptors by antagonist KH-5

2026-01-15

Abstract excerpt

<h4>Background and purpose</h4> Muscarinic acetylcholine receptors are key therapeutic targets, and ligands engaging both orthosteric and allosteric sites may offer improved selectivity and efficacy. The muscarinic antagonist KH-5 displays functional antagonistic potency exceeding its binding affinity, suggesting a non-classical mechanism of action. Here, we investigated whether KH-5 acts as a dualsteric antagoni...

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Literature Corpus work: 72d0c39a-e288-5413-b23f-d5aaef87a301
DOI: 10.64898/2026.01.15.699667

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