Back to search

Article

Identification of functionally connected multi-omic biomarkers for Alzheimer’s Disease using modularity-constrained Lasso

2019-10-02

Abstract excerpt

In the past decade, a large number of genetic biomarkers have been discovered through large-scale genome wide association studies (GWASs) in Alzheimer’s disease (AD), such as APOE, TOMM40 and CLU . Despite this significant progress, existing genetic findings are largely passengers not directly involved in the driver events, which presents challenges for replication and translation into targetable mechanisms. In...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c649f7a0-aa82-55a2-8f36-8145d3db6fbb
DOI
10.1101/789693
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Identification of functionally connected multi-omic biomarkers for Alzheimer’s Disease using modularity-constrained LassoDOI 10.1101/789693
Identification of functionally connected multi-omic biomarkers for Alzheimer's disease using modularity-constrained Lasso.Semantic proximity
Integrative-omics for discovery of network-level disease biomarkers: a case study in Alzheimer's disease.Semantic proximity
A large scale multivariate parallel ICA method reveals novel imaging-genetic relationships for Alzheimer's disease in the ADNI cohort.Semantic proximity
Modeling genotype-protein interaction and correlation for Alzheimer's disease: a multi-omics imaging genetics study.Semantic proximity
inMTSCCA: An Integrated Multi-task Sparse Canonical Correlation Analysis for Multi-omics Brain Imaging GeneticsSemantic proximity
Transcriptomic Stratification of Late-Onset Alzheimer’s Cases Reveals Novel Genetic Modifiers of Disease PathologySemantic proximity
Deep Trans-Omic Network Fusion for Molecular Mechanism of Alzheimer's Disease.Semantic proximity
Transcriptomic stratification of late-onset Alzheimer's cases reveals novel genetic modifiers of disease pathology.Semantic proximity
Towards prediction and prioritization of disease genes by the modularity of human phenome-genome assembled network.Semantic proximity
Multi-kernel linear mixed model with adaptive lasso for prediction analysis on high-dimensional multi-omics data.Semantic proximity
ADAPTIVE TESTING OF SNP-BRAIN FUNCTIONAL CONNECTIVITY ASSOCIATION VIA A MODULAR NETWORK ANALYSIS.Semantic proximity
A telescope GWAS analysis strategy, based on SNPs-genes-pathways ensamble and on multivariate algorithms, to characterize late onset Alzheimer's disease.Semantic proximity
Select a neighboring publication to make it the new centre.