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Article

Identification of functionally connected multi-omic biomarkers for Alzheimer's disease using modularity-constrained Lasso.

PloS one - 1 Jan 2020

Xie Linhui, Varathan Pradeep, Nho Kwangsik, Saykin Andrew J, Salama Paul, Yan Jingwen

Abstract excerpt

Large-scale genome wide association studies (GWASs) have led to discovery of many genetic risk factors in Alzheimer's disease (AD), such as APOE, TOMM40 and CLU. Despite the significant progress, it remains a major challenge to functionally validate these genetic findings and translate them into targetable mechanisms. Integration of multiple types of molecular data is increasingly used to address this problem. In...

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Source

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Identifiers

PMID: 32555747
DOI: 10.1371/journal.pone.0234748
PMCID: PMC7299377

Genes

APOE
CLU
TOMM40

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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