Article

Reduced triacylglycerols and lipid droplets are associated with resilience to Alzheimer’s disease

2025-05-14

Abstract excerpt

<h4>Introduction</h4> While it has become clear that alterations in lipid metabolism are associated with AD, it is unclear how they contribute to both cognitive decline and the pathophysiology of AD. <h4>Methods</h4> We performed lipidomics and activity-based protein profiling in the frontal cortex of control, AD and resilient donors, i.e. individuals with AD pathology without cognitive decline. Subsequently we...

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Literature Corpus work: c62fdbf3-587f-5ba0-921c-381a7b6a5ce1
DOI: 10.1101/2025.05.08.652735

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