Article

Dose-related biphasic effect of the Parkinson’s disease neurotoxin MPTP, on the spread, accumulation, and toxicity of α-synuclein

2020-11-03

Abstract excerpt

<h4>Background: </h4> 1-methyl, 4-phenyl, 1,2,3,6 tetrahydropyridine (MPTP), a mitochondrial neurotoxin, has been used previously to generate a PD mouse model. However, MPTP does not induce Lewy bodies or α-syn aggregation in mice. In the present study, we evaluated the effect of different doses of MPTP (10 mg/kg.b.wt and/or 25 mg/kg.b.wt) on the spread, accumulation, and toxicity of endogenous α-syn in mice admin...

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Literature Corpus work: 8380ad58-857a-5711-aba6-2f18f07be0fb
DOI: 10.21203/rs.3.rs-100202/v1

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