Article

Co-regulation and functional cooperativity of FOXM1 and RHNO1 bidirectional genes in ovarian cancer

2019-05-07

Abstract excerpt

<h4>Summary</h4> We report that the oncogenic transcription factor FOXM1 is arranged in a head-to-head configuration with RHNO1 , a gene involved in the ATR/CHK1-dependent DNA replication stress (DRS) response. FOXM1 and RHNO1 are both amplified and upregulated in high-grade serous ovarian cancer (HGSC). FOXM1 and RHNO1 expression are closely associated in normal and cancer tissues, including single cells,...

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Literature Corpus work: c612d6ac-5b61-59bf-9da7-d8c20aa123bd
DOI: 10.1101/630442

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