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Article

Circadian rhythm disruption induces PCOS-like phenotypes by interfering with ovarian steroid hormone synthesis pathways.

The Journal of steroid biochemistry and molecular biology - 1 May 2026

Feng ChengYu, Guo LiYing, Gao Xin, Ji Xia, Liu Ying, Liu JiWei, Liu ShuJun, Liu Yang, Ma LiBing, He XiaoYing

Abstract excerpt

Stressors are a critical contributor to reproductive dysfunction. This study investigated whether experimentally induced chronic stress leads to infertility and elucidated its disruptive mechanisms on the female reproductive endocrine system. Three chronic stress models were established in female ICR mice: chronic restraint stress (CRS), circadian rhythm disruption (CR), and chronic unpredictable mild stress...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41771452
DOI: 10.1016/j.jsbmb.2026.106980

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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